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Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation.
- Source :
-
Journal of neurophysiology [J Neurophysiol] 2007 Mar; Vol. 97 (3), pp. 2564-9. Date of Electronic Publication: 2006 Oct 11. - Publication Year :
- 2007
-
Abstract
- Neuron-glia signaling is important for neural development and functions. This signaling may be regulated by neuronal activity and undergo modification similar to long-term potentiation (LTP) of neuronal synapses, a hallmark of neuronal plasticity. We found that tetanic stimulation of Schaffer collaterals (Sc) in the hippocampus that induced LTP in neurons also resulted in LTP-like persistent elevation of Sc-evoked slow depolarization in perisynaptic astrocytes. The elevated slow depolarization in astrocytes was abolished by NMDA receptor antagonist and K(+) channel inhibitors, but not by Ca(2+) chelator BAPTA loaded in the recorded astrocytes, suggesting involvement of an increased extracellular K(+) accumulation accompanying LTP of neuronal synapses. The increased K(+) accumulation and astrocyte depolarization after LTP induction may reduce the efficiency of glial glutamate transporters, which may contribute to the enhanced synaptic efficacy. The neuronal activity-induced persistent enhancement of neuron-glia signaling may thus have important physiological relevance.
- Subjects :
- 2-Amino-5-phosphonovalerate pharmacology
Animals
Animals, Newborn
Chelating Agents pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Egtazic Acid analogs & derivatives
Egtazic Acid pharmacology
Electric Stimulation
Excitatory Amino Acid Antagonists pharmacology
Excitatory Postsynaptic Potentials drug effects
Excitatory Postsynaptic Potentials physiology
Excitatory Postsynaptic Potentials radiation effects
Hippocampus cytology
In Vitro Techniques
Long-Term Potentiation drug effects
Long-Term Potentiation radiation effects
Neuroglia drug effects
Neuroglia radiation effects
Neurons drug effects
Neurons radiation effects
Patch-Clamp Techniques methods
Potassium pharmacology
Potassium Channel Blockers pharmacology
Rats
Signal Transduction drug effects
Extracellular Space metabolism
Long-Term Potentiation physiology
Neuroglia physiology
Neurons physiology
Potassium metabolism
Signal Transduction physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3077
- Volume :
- 97
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 17035364
- Full Text :
- https://doi.org/10.1152/jn.00146.2006