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Successful treatment of recalcitrant necrotizing eosinophilic folliculitis using indomethacin and cephalexin.
- Source :
-
The Australasian journal of dermatology [Australas J Dermatol] 2006 Nov; Vol. 47 (4), pp. 281-5. - Publication Year :
- 2006
-
Abstract
- A 56-year-old man presented with a 4-month history of a painful and pruritic eruption consisting of crusted plaques and blisters on his face, scalp and chest. The patient suffered from headaches and malaise but was afebrile. Two skin biopsies revealed an epidermis which was eroded and covered by locules of serum and neutrophils. In the underlying dermis, there was a marked mixed inflammatory reaction including lymphocytes, neutrophils and numerous eosinophils. There was exocytosis of eosinophils into several follicles with areas of follicular mucinosis. A diagnosis of necrotizing eosinophilic folliculitis was made based upon the clinical and histopathological findings. The diagnosis was supported by the rapid response to a combination of indomethacin and cephalexin. The patient has taken continuous indomethacin (with rabeprazole and misoprostol cover) and cephalexin for 2 years. If treatment is withdrawn he experiences a flare of his disease within 2 weeks. This case highlights the potentially chronic nature of this disease.
- Subjects :
- Administration, Oral
Anti-Bacterial Agents administration & dosage
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Cephalexin administration & dosage
Cephalexin therapeutic use
Diagnosis, Differential
Drug Therapy, Combination
Eosinophilia complications
Eosinophilia diagnosis
Eosinophilia drug therapy
Eosinophilia pathology
Face pathology
Folliculitis complications
Folliculitis drug therapy
Folliculitis pathology
Humans
Indomethacin administration & dosage
Indomethacin therapeutic use
Male
Middle Aged
Pruritus etiology
Recurrence
Scalp pathology
Thorax pathology
Folliculitis diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0004-8380
- Volume :
- 47
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Australasian journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 17034473
- Full Text :
- https://doi.org/10.1111/j.1440-0960.2006.00296.x