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[Two cases of advanced pancreatic cancer with cervical lymph node or liver metastasis responding well to S-1 monotherapy].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2006 Oct; Vol. 33 (10), pp. 1505-9. - Publication Year :
- 2006
-
Abstract
- In two patients with advanced pancreatic cancer with cervical lymph node or liver metastasis and no indication of pancreatic resection and radiotherapy, oral treatment with S-1 (an anti-cancer agent of fluoropyrimidine derivative) exerted high anti-tumor activity on the metastatic lesions. Both cases responded well to this therapy in the late phase II study of S-1 in patients with advanced pancreatic cancer designed to evaluate efficacy and safety. In Case 1 (with cervical lymph node metastasis), the anti-tumor efficacy of this therapy was evaluated as a partial response (PR) after the first four courses of treatment. In Case 2 (with liver metastasis), the efficacy was evaluated as PR for overall response. Thus, the therapy indicated excellent efficacy in both cases. No grade 3 or severe adverse event was noted in either of the two cases. In Case 1, grade 2 anemia, stomatitis, vomiting and fatigue, and some other mild events were noted. When used as a systemic chemotherapy for metastatic pancreatic cancer, oral treatment of S-1 is highly effective, tolerable and convenient in an outpatient clinic. This drug is a promising way to improve and preserve the QOL essential to long-term home care.
- Subjects :
- Adenocarcinoma secondary
Administration, Oral
Aged
Anemia chemically induced
Antimetabolites, Antineoplastic adverse effects
Drug Administration Schedule
Drug Combinations
Female
Humans
Liver Neoplasms drug therapy
Lymphatic Metastasis
Male
Middle Aged
Neck
Oxonic Acid adverse effects
Pancreatic Neoplasms pathology
Quality of Life
Stomatitis chemically induced
Tegafur adverse effects
Vomiting, Anticipatory etiology
Adenocarcinoma drug therapy
Antimetabolites, Antineoplastic administration & dosage
Liver Neoplasms secondary
Lymph Nodes pathology
Oxonic Acid administration & dosage
Pancreatic Neoplasms drug therapy
Tegafur administration & dosage
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 33
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 17033248