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Administration of temozolomide during and after radiotherapy for newly diagnosed high-grade gliomas excluding glioblastoma multiforme.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2007 Feb; Vol. 81 (3), pp. 323-5. Date of Electronic Publication: 2006 Sep 23. - Publication Year :
- 2007
-
Abstract
- Primary brain high-grade gliomas, excluding glioblastoma are rare and heterogeneous tumors, showing different characteristic mutations and a better prognosis than glioblastomas. The addition of chemotherapy to the radiotherapy in the newly diagnosed disease has not been established yet. We treated 9 patients with newly diagnosed tumors with temozolomide at 75 mg/m2 for 7 days a week during standard radiotherapy, followed by six cycles at 200 mg/m2 on days 1-5 every 28 days. Fluorescence in situ hybridization for the 1 p/19 q loss was performed in seven out of the 9 patients. With a median follow-up of 15 months (range, 8-50), eight patients are alive and one died from disease progression. Four patients had disease progression at 7, 15, 14 and 13 months from the diagnosis. The 1 p/19 q loss was found in 5 patients; three have no evidence of disease, one had partial disease remission and one disease progression. Toxicities included one discitis requiring treatment withdrawal and specific antibiotic therapy, and one transient grade 3 psoriasiform reaction. Based on this small series of patients, the addition of temozolomide to radiotherapy may be recommended.
- Subjects :
- Brain Neoplasms mortality
Brain Neoplasms radiotherapy
Combined Modality Therapy
Dacarbazine therapeutic use
Glioma mortality
Glioma radiotherapy
Humans
Survival Analysis
Temozolomide
Antineoplastic Agents therapeutic use
Brain Neoplasms drug therapy
Dacarbazine analogs & derivatives
Glioma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0167-594X
- Volume :
- 81
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 17031557
- Full Text :
- https://doi.org/10.1007/s11060-006-9234-x