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Immunoregulatory T cells in B cell chronic lymphocytic leukaemia: evidence of a unique phenotype a flow cytometric study.
- Source :
-
Disease markers [Dis Markers] 1990 May-Jun; Vol. 8 (3), pp. 137-43. - Publication Year :
- 1990
-
Abstract
- CD4+ T cells of 57 patients with B cell chronic lymphocytic leukaemia (CLL) were analysed for expression of CD45RA and CD29. The majority of CLL patients (33 cases) showed a novel coexpression of these markers on a significant proportion of CD4+ T cells; however, analysis of a single blood sample revealed no apparent prognostic value associated with the markers. Expression of CD45RA and CD29 correlated with parameters of immune function consistent with the known attributes of these markers.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antigens, Differentiation analysis
Antigens, Neoplasm analysis
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers
Female
Flow Cytometry
Histocompatibility Antigens analysis
Humans
Immunoglobulins analysis
Immunophenotyping
Integrin beta1
Leukemia, Lymphocytic, Chronic, B-Cell blood
Leukemia, Lymphocytic, Chronic, B-Cell drug therapy
Leukocyte Common Antigens
Male
Middle Aged
T-Lymphocytes immunology
Antigens, Differentiation, T-Lymphocyte analysis
Leukemia, Lymphocytic, Chronic, B-Cell pathology
T-Lymphocyte Subsets pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0278-0240
- Volume :
- 8
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Disease markers
- Publication Type :
- Academic Journal
- Accession number :
- 1703059