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IgM anti-idiotypes that block anti-HLA antibodies: naturally occurring or immune antibodies?
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 1991 Jan; Vol. 83 (1), pp. 116-20. - Publication Year :
- 1991
-
Abstract
- Using dithiothreitol (DTT) technique, IgM anti-HLA anti-idiotypic antibodies were detected in a multiparous multitransfused woman. These antibodies were able to inhibit the binding of specific IgG anti-HLA antibodies on their corresponding antigen. The recognized determinants were cross-reactive determinants since they were partially found on anti-HLA antibodies from unrelated individuals. By studying the patient's sera over a period of 2 years, no IgM-IgG switch was observed but the presence of these antibodies was stable in time, despite the disappearance of the idiotypes (anti-HLA antibodies). However, when looking at the patient's earlier serum, it was shown that these IgM anti-idiotypic antibodies were absent from the first available serum. Thus, these anti-idiotypic antibodies seem to behave both like natural and immune antibodies. The incidence of such antibodies in pretransplant patients is discussed.
- Subjects :
- Adult
Antibodies, Anti-Idiotypic analysis
Blood Transfusion
Cytotoxicity, Immunologic immunology
Dithiothreitol
Epitopes immunology
Female
Humans
Immunoglobulin G immunology
Immunoglobulin M analysis
Kidney Diseases immunology
Renal Dialysis
Time Factors
Antibodies, Anti-Idiotypic immunology
HLA Antigens immunology
Immunoglobulin M immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 83
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 1703054
- Full Text :
- https://doi.org/10.1111/j.1365-2249.1991.tb05599.x