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Exposure to Alternaria alternata in US homes is associated with asthma symptoms.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2006 Oct; Vol. 118 (4), pp. 892-8. - Publication Year :
- 2006
-
Abstract
- Background: Exposure to the fungus Alternaria alternata is a risk factor for asthma. Few studies have examined Alternaria exposures in indoor environments.<br />Objective: We examined whether exposure to A alternata in US homes was associated with asthma-related outcomes.<br />Methods: The data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed a nationally representative sample of 831 housing units inhabited by 2456 individuals in 75 different locations throughout the United States. An interviewer-administered questionnaire obtained information on demographics, household characteristics, and occupants' health status. Exposure to A alternata was assessed by measuring concentrations of A alternata antigens in vacuumed dust samples using a polyclonal anti-A alternata antibody assay. Dust samples were collected from a bed, a sofa, or a chair, and from bedroom, living room, and kitchen floors.<br />Results: Lifetime prevalence of doctor-diagnosed asthma was 11.2%, and 6.9% of the study subjects reported active asthma symptoms in the past 12 months. The prevalence of current symptomatic asthma increased with increasing Alternaria concentrations in US homes; higher levels of A alternata antigens increased the odds of having asthma symptoms in the past year (relative to the lowest tertile, adjusted odds ratio was 1.52, 95% CI, 0.90-2.55 for the 2nd tertile; and 1.84, 95% CI, 1.18-2.85 for the 3rd tertile).<br />Conclusion: Exposure to A alternata in US homes is associated with active asthma symptoms.<br />Clinical Implications: Measures that reduce indoor exposure to A alternata may help control asthma exacerbations.
Details
- Language :
- English
- ISSN :
- 0091-6749
- Volume :
- 118
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 17030243
- Full Text :
- https://doi.org/10.1016/j.jaci.2006.07.037