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Montmorillonite ameliorates hyperthyroidism of rats and mice attributed to its adsorptive effect.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2006 Dec 03; Vol. 551 (1-3), pp. 156-61. Date of Electronic Publication: 2006 Sep 07. - Publication Year :
- 2006
-
Abstract
- The present study aims to evaluate the adsorbing effect of montmorillonite on thyroid hormone in the entero-hepatic circulation. The concentration of thyroid hormone in the serum of hyperthyroidism model rats and in solution was measured by radioimmunoassay and ultraviolet spectrometry, respectively. The body weight, temperature, and consumption of food and water were observed in hyperthyroidism model rats. Furthermore, hypoxia tolerance, sodium-pentobarbital-induced sleep time, spontaneous activities were measured on hyperthyroidism model mice after being treated with montmorillonite. Results showed that montmorillonite adsorbed thyroxin (T(4)) and triiodothyronine (T(3)) in vitro. Montmorillonite at dosage of 1.0 g/kg and 0.3 g/kg decreased thyroid hormone levels on hyperthyroidism model rats; Montmorillonite (2.0 g/kg and 0.6 g/kg) prolonged the sleep time, improved the hypoxia tolerant capacity and reduced the spontaneous activities of the hyperthyroidism model mice. These results suggest montmorillonite has anti-hyperthyroidism effect attributed to its adsorptive effect.
- Subjects :
- Adsorption drug effects
Animals
Antithyroid Agents chemistry
Bentonite chemistry
Disease Models, Animal
Dose-Response Relationship, Drug
Drinking drug effects
Eating drug effects
Hyperthyroidism blood
Hyperthyroidism physiopathology
Hypoxia physiopathology
Male
Mice
Mice, Inbred ICR
Motor Activity drug effects
Rats
Rats, Sprague-Dawley
Sleep drug effects
Thyroxine blood
Thyroxine chemistry
Time Factors
Triiodothyronine blood
Triiodothyronine chemistry
Antithyroid Agents pharmacology
Antithyroid Agents therapeutic use
Bentonite pharmacology
Bentonite therapeutic use
Hyperthyroidism drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 551
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 17027745
- Full Text :
- https://doi.org/10.1016/j.ejphar.2006.08.053