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Thermoreversible-mucoadhesive gel for nasal delivery of sumatriptan.
- Source :
-
AAPS PharmSciTech [AAPS PharmSciTech] 2006 Aug 04; Vol. 7 (3), pp. 67. Date of Electronic Publication: 2006 Aug 04. - Publication Year :
- 2006
-
Abstract
- The purpose of the present study was to develop intranasal delivery systems of sumatriptan using thermoreversible polymer Pluronic F127 (PF127) and mucoadhesive polymer Carbopol 934P (C934P). Formulations were modulated so as to have gelation temperature below 34 degrees C to ensure gelation at physiological temperature after intranasal administration. Gelation temperature was determined by physical appearance as well as by rheological measurement. The gelation temperatures of the formulations decreased by addition of increasing concentrations of Carbopol (ie, from 29 degrees C for 18% PF127 to 23.9 degrees C for 18% PF127, 0.5% Carbopol). The mucoadhesive force in terms of detachment stress, determined using sheep nasal mucosal membrane, increased with increasing concentration of Carbopol. The results of in vitro drug permeation studies across sheep nasal mucosa indicate that effective permeation coefficient could be significantly increased by using in situ gelling formulation with Carbopol concentration 0.3% or greater. Finally, histopathological examination did not detect any damage during in vitro permeation studies. In conclusion, the PF127 gel formulation of sumatriptan with in situ gelling and mucoadhesive properties with increased permeation rate is promising for prolonging nasal residence time and thereby nasal absorption.
- Subjects :
- Adhesives administration & dosage
Drug Administration Routes
Drug Delivery Systems
Gels administration & dosage
Gels chemistry
Humans
Mucous Membrane chemistry
Mucous Membrane drug effects
Poloxamer administration & dosage
Poloxamer chemistry
Adhesives chemistry
Administration, Intranasal
Serotonin Receptor Agonists administration & dosage
Sumatriptan administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1530-9932
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- AAPS PharmSciTech
- Publication Type :
- Academic Journal
- Accession number :
- 17025248
- Full Text :
- https://doi.org/10.1208/pt070367