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Extrinsic projections from area CA1 of the rat hippocampus: olfactory, cortical, subcortical, and bilateral hippocampal formation projections.
- Source :
-
The Journal of comparative neurology [J Comp Neurol] 1990 Dec 15; Vol. 302 (3), pp. 515-28. - Publication Year :
- 1990
-
Abstract
- Hippocampal area CA1 provides the major cortical output of the hippocampus, but only its projections to the subiculum and lateral septal nucleus are well characterized. The present study reexamines these extrinsic projections by using anterograde and retrograde tracing techniques. Injections of the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L) in the septal one-third of CA1 label axons and terminals in subicular, postsubicular, retrosplenial, perirhinal, and entorhinal cortices, lateral septal nucleus, and diagonal band of Broca. The septal CA1 injections also label terminal fields in contralateral CA1, and in contralateral subicular, postsubicular, perirhinal, and entorhinal cortices. Injections into the splenial one-third of CA1 label axons and terminals in subiculum, postsubiculum, ventral area infraradiata, and lateral septal nucleus, but they do not label axons and terminals on the contralateral side of the brain. Injections in the temporal one-third of CA1 label axons and terminals in subicular, parasubicular, entorhinal, and infraradiata cortices, anterior olfactory nucleus, olfactory bulb, lateral septal nucleus, nucleus accumbens, amygdala, and hypothalamus. The temporal CA1 injections label no axons on the contralateral side of the brain. These data demonstrate that CA1 has more widespread projections than previously appreciated, and they provide the first clear evidence that CA1 projects to the contralateral cortex and to the ipsilateral olfactory bulb, amygdala, and hypothalamus. The results also demonstrate a heterogeneity in the efferent projections originating in different septotemporal levels of CA1.
- Subjects :
- Afferent Pathways anatomy & histology
Afferent Pathways physiology
Animals
Axonal Transport
Axons physiology
Axons ultrastructure
Efferent Pathways anatomy & histology
Efferent Pathways physiology
Functional Laterality
Hippocampus physiology
Male
Microscopy, Fluorescence
Olfactory Bulb physiology
Phytohemagglutinins
Pyramidal Tracts physiology
Rats
Rats, Inbred Strains
Hippocampus anatomy & histology
Olfactory Bulb anatomy & histology
Pyramidal Tracts anatomy & histology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9967
- Volume :
- 302
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of comparative neurology
- Publication Type :
- Academic Journal
- Accession number :
- 1702115
- Full Text :
- https://doi.org/10.1002/cne.903020308