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Cognitive-behavioral therapy for PANDAS-related obsessive-compulsive disorder: findings from a preliminary waitlist controlled open trial.
- Source :
-
Journal of the American Academy of Child and Adolescent Psychiatry [J Am Acad Child Adolesc Psychiatry] 2006 Oct; Vol. 45 (10), pp. 1171-8. - Publication Year :
- 2006
-
Abstract
- Objective: To provide preliminary estimates of the effectiveness of cognitive-behavioral therapy (CBT) in treating pediatric obsessive-compulsive disorder (OCD) of the pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS) subtype.<br />Method: Seven children with OCD of the PANDAS subtype (range 9-13 years) were treated in a 3-week intensive CBT program conducted at a university clinic. Six of seven children were taking selective serotonin reuptake inhibitor medication(s) upon presentation. Assessments were conducted at four time points: baseline, pretreatment approximately 4 weeks later, posttreatment, and 3-month follow-up. Raters were blind to the nature of the study treatment.<br />Results: Six of seven participants were classified as treatment responders (much or very much improved) at posttreatment, and three of six remained responders at follow-up. Clinician severity ratings, as measured by the Children's Yale-Brown Obsessive-Compulsive Scale and Anxiety Disorder Interview Schedule for DSM-IV Child Interview Schedule-Parent version, decreased significantly following intervention, with effect sizes of 3.38 and 2.29, respectively. Self-reported general anxiety and depression symptoms were not significantly reduced.<br />Conclusions: This study provides preliminary support for CBT in treating the PANDAS subtype of pediatric OCD. This approach is also considered a safe and minimally invasive treatment approach.
- Subjects :
- Adolescent
Child
Female
Humans
Male
Obsessive-Compulsive Disorder diagnosis
Surveys and Questionnaires
Syndrome
Autoantibodies immunology
Brain immunology
Brain microbiology
Central Nervous System Bacterial Infections complications
Cognitive Behavioral Therapy methods
Obsessive-Compulsive Disorder microbiology
Obsessive-Compulsive Disorder therapy
Streptococcal Infections complications
Streptococcus pyogenes
Subjects
Details
- Language :
- English
- ISSN :
- 0890-8567
- Volume :
- 45
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Child and Adolescent Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17003662
- Full Text :
- https://doi.org/10.1097/01.chi.0000231973.43966.a0