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Use of subcutaneous DDAVP in infants with central diabetes insipidus.
- Source :
-
Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2006 Jul; Vol. 19 (7), pp. 919-25. - Publication Year :
- 2006
-
Abstract
- Traditional methods for treating central diabetes insipidus during infancy, such as fluid therapy or the use of intranasal hormone replacement, have significant potential limitations. In a retrospective study of infants with diabetes insipidus, we examined outcome using subcutaneous (sc) DDAVP, and compared this to infants treated with intranasal lysine vasopressin or DDAVP. After in-patient dosage titration, outpatients' serum sodium concentrations were maintained in a narrower range in the sc group compared with the intranasal group, and the percentage of serum sodium concentrations within the normal range was greater in the sc group. There were no significant complications in either group. We conclude that DDAVP administered subcutaneously can be a safe and effective alternative to traditionally recommended treatments of central diabetes insipidus during infancy.
- Subjects :
- Administration, Intranasal
Child, Preschool
Female
Follow-Up Studies
Humans
Infant
Injections, Subcutaneous
Male
Retrospective Studies
Antidiuretic Agents administration & dosage
Deamino Arginine Vasopressin administration & dosage
Diabetes Insipidus, Neurogenic drug therapy
Lypressin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0334-018X
- Volume :
- 19
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of pediatric endocrinology & metabolism : JPEM
- Publication Type :
- Academic Journal
- Accession number :
- 16995572
- Full Text :
- https://doi.org/10.1515/jpem.2006.19.7.919