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HIV type 1 zidovudine (ZDV) resistance in blood and uterine cervical secretions of pregnant women.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2006 Sep; Vol. 22 (9), pp. 870-3. - Publication Year :
- 2006
-
Abstract
- To determine if HIV-1 resistance testing of the blood predicts mutants in the genital secretions of ZDV-treated pregnant women, ZDV resistance mutations were assessed by an oligonucleotide ligation assay. ZDV resistance was detected in viral sequences from blood (16/48; 33%) and cervical secretions (6/24; 25%) collected during 57 pregnancies. The genotype of 11/69 (16%) resistance codons was discordant between blood and cervical virus of pregnant women near term. However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract.
- Subjects :
- Biomarkers blood
Cervix Mucus virology
Drug Resistance, Viral physiology
Female
Genitalia, Female virology
HIV Infections drug therapy
HIV-1 genetics
Humans
Infectious Disease Transmission, Vertical prevention & control
Plasma virology
Pregnancy
RNA-Directed DNA Polymerase genetics
Anti-HIV Agents pharmacology
Drug Resistance, Viral genetics
HIV Infections prevention & control
HIV-1 drug effects
Pregnancy Complications, Infectious virology
Zidovudine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0889-2229
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 16989612
- Full Text :
- https://doi.org/10.1089/aid.2006.22.870