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Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide.
- Source :
-
AIDS (London, England) [AIDS] 2006 Oct 03; Vol. 20 (15), pp. 1977-9. - Publication Year :
- 2006
-
Abstract
- Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug-drug interaction warrants further investigation.
- Subjects :
- Anti-HIV Agents therapeutic use
Antiretroviral Therapy, Highly Active
Cohort Studies
Drug Interactions
Enfuvirtide
Female
HIV Envelope Protein gp41 therapeutic use
HIV Fusion Inhibitors pharmacokinetics
HIV Fusion Inhibitors therapeutic use
HIV Infections drug therapy
HIV Protease Inhibitors pharmacokinetics
HIV Protease Inhibitors therapeutic use
HIV-1
Half-Life
Humans
Male
Peptide Fragments therapeutic use
Pyridines therapeutic use
Pyrones therapeutic use
Ritonavir therapeutic use
Sulfonamides
Anti-HIV Agents pharmacokinetics
Peptide Fragments pharmacokinetics
Pyridines pharmacokinetics
Pyrones pharmacokinetics
Ritonavir pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0269-9370
- Volume :
- 20
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 16988521
- Full Text :
- https://doi.org/10.1097/01.aids.0000247121.19951.fa