Back to Search
Start Over
Needle-free injection of DNA vaccines: a brief overview and methodology.
- Source :
-
Methods in molecular medicine [Methods Mol Med] 2006; Vol. 127, pp. 83-9. - Publication Year :
- 2006
-
Abstract
- The development of needle-free injection originally stemmed from a general apprehension of needle injections, disease transmission by accidental needle-sticks, and the need for effective mass immunization. Naked DNA vaccines, as attractive and universal as they appear, have not produced robust immune responses in test systems. However, proof of principle for DNA vaccines has been validated with a number of vaccine candidates in a variety of test systems, and the concept of DNA vaccines as a generic platform for vaccines still remains viable and attractive. Many avenues are being explored to enhance the immunogenicity of DNA vaccines. The easiest and most straightforward approach that can be quickly transitioned to a clinical trial setting is vaccine delivery by a needle-free jet injector. This approach has shown much potential in a number of cases and should become the lead method for enhancing DNA vaccines. This approach requires no additional development, and with an expanding market and willingness from jet injector manufacturers to produce prefilled syringes, the technique should become feasible for larger phase II/phase III trials.
- Subjects :
- Animals
Clinical Trials, Phase II as Topic
Clinical Trials, Phase III as Topic
Humans
Injections, Intradermal instrumentation
Injections, Intradermal methods
Injections, Intramuscular instrumentation
Injections, Intramuscular methods
Injections, Jet instrumentation
Injections, Jet methods
Mice
Primates
Vaccination instrumentation
Vaccination methods
Vaccines, DNA administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1543-1894
- Volume :
- 127
- Database :
- MEDLINE
- Journal :
- Methods in molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16988448
- Full Text :
- https://doi.org/10.1385/1-59745-168-1:83