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Effect of gonadotropin-releasing hormone analogue on thermal nociception in mice.

Authors :
Bobyntsev II
Sever'yanova LA
Kryukov AA
Source :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2006 Feb; Vol. 141 (2), pp. 193-6.
Publication Year :
2006

Abstract

Intraperitoneal treatment with an analogue of gonadotropin-releasing hormone in doses of 0.004-450 microg/kg produced an analgesic effect on male mice in the hot plate test. Castration significantly elevated the nociceptive thresholds. In castrated mice the effects of the test peptide were less pronounced and had an algesic nature. Our results indicate that these effects depend on functional activity of the hypothalamic-pituitary-gonadal axis.

Details

Language :
English
ISSN :
0007-4888
Volume :
141
Issue :
2
Database :
MEDLINE
Journal :
Bulletin of experimental biology and medicine
Publication Type :
Academic Journal
Accession number :
16984094
Full Text :
https://doi.org/10.1007/s10517-006-0125-0