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Effect of gonadotropin-releasing hormone analogue on thermal nociception in mice.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2006 Feb; Vol. 141 (2), pp. 193-6. - Publication Year :
- 2006
-
Abstract
- Intraperitoneal treatment with an analogue of gonadotropin-releasing hormone in doses of 0.004-450 microg/kg produced an analgesic effect on male mice in the hot plate test. Castration significantly elevated the nociceptive thresholds. In castrated mice the effects of the test peptide were less pronounced and had an algesic nature. Our results indicate that these effects depend on functional activity of the hypothalamic-pituitary-gonadal axis.
- Subjects :
- Analgesics pharmacology
Animals
Gonadotropin-Releasing Hormone pharmacology
Hot Temperature
Hypothalamo-Hypophyseal System drug effects
Hypothalamo-Hypophyseal System physiology
Male
Mice
Mice, Inbred BALB C
Nociceptors physiology
Orchiectomy
Pain Measurement
Pain Threshold drug effects
Pituitary-Adrenal System drug effects
Pituitary-Adrenal System physiology
Testis physiology
Gonadotropin-Releasing Hormone analogs & derivatives
Nociceptors drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0007-4888
- Volume :
- 141
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16984094
- Full Text :
- https://doi.org/10.1007/s10517-006-0125-0