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CXCL16 regulates cell-mediated immunity to Salmonella enterica serovar Enteritidis via promotion of gamma interferon production.
- Source :
-
Infection and immunity [Infect Immun] 2006 Dec; Vol. 74 (12), pp. 6885-94. Date of Electronic Publication: 2006 Sep 18. - Publication Year :
- 2006
-
Abstract
- CXCL16 is a recently discovered multifaceted chemokine that has been shown not only to recruit activated T lymphocytes but also to play a direct role in the binding and phagocytosis of bacteria by professional antigen-presenting cells. In this study, we investigated the role of CXCL16 in vivo in the regulation of the immune response using a murine model of Salmonella enterica serovar Enteritidis infection. The expression of CXCL16 was strongly upregulated in the spleens and livers of animals developing an immune response to a primary acute infection but not in the Peyer's patches. Animals developing a secondary response after reexposure to the bacteria displayed a similar pattern of expression. During the primary response, prior treatment with neutralizing antibodies to CXCL16 induced a significant increase in bacterial burden in the spleen and liver. The production of gamma interferon (IFN-gamma) by the lymphocytes in the spleen was decreased by anti-CXCL16 treatment. In comparison, during the secondary response, anti-CXCL16 treatment also significantly increased bacterial burden in both the spleen and liver but had no effect on IFN-gamma production. No role was found for CXCL16 in the production of antibody against SefA, a major surface antigen of S. enteritidis. Together, these results demonstrate a role for CXCL16 in the control of bacterial colonization of target organs and, more specifically, in the regulation of the cell-mediated arm of the primary response to S. enteritidis.
- Subjects :
- Animals
Antibodies, Blocking immunology
Antibodies, Blocking pharmacology
Chemokine CXCL10
Chemokine CXCL11
Chemokine CXCL16
Chemokine CXCL6
Chemokine CXCL9
Chemokines, CXC antagonists & inhibitors
Chemokines, CXC genetics
Chemokines, CXC metabolism
Female
Interferon-gamma analysis
Lymphocytes immunology
Mice
Mice, Inbred BALB C
Receptors, Scavenger antagonists & inhibitors
Receptors, Scavenger genetics
Salmonella Infections genetics
Up-Regulation
Chemokines, CXC physiology
Interferon-gamma metabolism
Receptors, Scavenger physiology
Salmonella Infections immunology
Salmonella enteritidis
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 74
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 16982830
- Full Text :
- https://doi.org/10.1128/IAI.01065-06