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Fabrication of polymeric replicas of cell surfaces with nanoscale resolution.
- Source :
-
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2006 Sep 26; Vol. 22 (20), pp. 8266-70. - Publication Year :
- 2006
-
Abstract
- We report an approach for fabricating biomimetic surface replicas of cells with nanoscale resolution. Fixed cells serve as a template for a two-stage replica molding process. Cast from the template, the impression replica contains a reproduction of cellular topographical features indented into its surface, and cast from the impression replica, the relief replica contains a copy of these features protruding from its surface. Various polymers and cells can be utilized, and scanning electron microscopy, atomic force microscopy, and white light interferometry analyses confirm the replication of nanoscale features. These replicas are useful for investigating cellular function and for biomimetic tissue engineering.
Details
- Language :
- English
- ISSN :
- 0743-7463
- Volume :
- 22
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Langmuir : the ACS journal of surfaces and colloids
- Publication Type :
- Academic Journal
- Accession number :
- 16981733
- Full Text :
- https://doi.org/10.1021/la0608563