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Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defects.
- Source :
-
Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2006 Dec; Vol. 94 (2), pp. 302-9. Date of Electronic Publication: 2006 Sep 15. - Publication Year :
- 2006
-
Abstract
- The present study shows that polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) can interact and enhance developmental neurobehavioral defects when the exposure occurs during a critical stage of neonatal brain development. PBDEs are used in large quantities as flame-retardant additives in polymers, especially in the manufacture of a great variety of electrical appliances, and textiles. In contrast to the well-known persistent compounds PCBs and DDT, the PBDEs have been found to increase in the environment and in human mother's milk. We have previously shown that low-dose exposure to environmental toxic agents such as PCB can cause developmental neurotoxic effects when present during a critical stage of neonatal brain development. Epidemiological studies indicate the adverse neurobehavioral impact of PCBs. Recently, we reported that neonatal exposure to PBDEs causes developmental neurotoxic effects. In the present study, 10-day-old Naval Medical Research Institute male mice were given one single oral dose of PCB 52 (1.4 micromol/kg body weight [bw]) + PBDE 99 (1.4 micromol), PCB 52 (1.4 micromol or 14 micromol), or PBDE 99 (1.4 micromol or 14 micromol). Controls received a vehicle (20% fat emulsion). Animals exposed to the combined dose of PCB 52 (1.4 micromol) + PBDE 99 (1.4 micromol) and the high dose of PCB 52 (14 micromol) or PBDE 99 (14 micromol) showed significantly impaired spontaneous motor behavior and habituation capability at the age of 4 and 6 months. The neurobehavioral defects were also seen to worsen with age in mice neonatally exposed to PCB 52 + PBDE 99.
- Subjects :
- Animals
Animals, Suckling
Dose-Response Relationship, Drug
Drug Interactions
Drug Therapy, Combination
Habituation, Psychophysiologic drug effects
Halogenated Diphenyl Ethers
Male
Mice
Motor Activity drug effects
Nervous System growth & development
Nervous System physiopathology
Behavior, Animal drug effects
Environmental Pollutants toxicity
Flame Retardants toxicity
Nervous System drug effects
Phenyl Ethers toxicity
Polybrominated Biphenyls toxicity
Polychlorinated Biphenyls toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1096-6080
- Volume :
- 94
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxicological sciences : an official journal of the Society of Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 16980691
- Full Text :
- https://doi.org/10.1093/toxsci/kfl109