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Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2006 Aug; Vol. 29 (8), pp. 685-90. - Publication Year :
- 2006
-
Abstract
- The effect of a main constituent ginsenoside Rg5 isolated from red ginseng and its metabolite ginsenoside Rh3 in a chronic dermatitis model was investigated. Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis. These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. The inhibition of ginsenoside Rh3 was more potent than that of ginsenoside Rg5. These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1beta and TNF-alpha produced by macrophage cells and of IFN-gamma produced by Th cells.
- Subjects :
- Animals
Chronic Disease
Cyclooxygenase 2 biosynthesis
Dermatitis, Contact etiology
Dermatitis, Contact metabolism
Female
Ginsenosides metabolism
Interferon-gamma biosynthesis
Interleukin-1beta biosynthesis
Mice
Mice, Inbred ICR
Oxazolone
Tumor Necrosis Factor-alpha biosynthesis
Dermatitis, Contact drug therapy
Ginsenosides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0253-6269
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 16964764
- Full Text :
- https://doi.org/10.1007/BF02968253