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HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2006 Oct 01; Vol. 194 (7), pp. 917-25. Date of Electronic Publication: 2006 Aug 29. - Publication Year :
- 2006
-
Abstract
- Background: Human immunodeficiency virus (HIV)-1 infected adults with low CD4 cell count have a higher risk of malaria infection and clinical malaria. We assessed the influence that HIV-1 immune suppression has on the efficacy of antimalarial treatment in adults with uncomplicated malaria.<br />Methods: This clinical trial included 971 Zambian adults with uncomplicated malaria. Patients were tested for HIV-1, and, if positive, a CD4 cell count was assessed. The primary outcome was recurrent parasitemia corrected by molecular genotyping within 45 days after treatment.<br />Results: HIV-1 infection was detected in 33% (320/971) of adult patients with malaria. Treatment failure was not associated with HIV-1 infection (relative risk [RR], 1.12 [95% confidence interval {CI}, 0.82-1.53]; P=.45). HIV-1-infected patients with a CD4 cell count <300 cells/microL had an increased risk of recurrent parasitemia, compared with those with a CD4 cell count >or=300 cells/microL (RR, 2.24 [95% CI, 1.20-4.14]; P=.01). After genotyping, the risk of recrudescence was higher in HIV-1-infected patients with a CD4 cell count <300 cells/microL than in the other patients with malaria (RR, 1.67 [95% CI, 1.13-2.47]; P=.02).<br />Conclusion: HIV-1-infected patients with malaria with a CD4 cell count <300 cells/microL have a higher risk of experiencing a recrudescent infection, compared with those with a CD4 cell count >or=300 cells/microL or without HIV-1 infection. Trial registered at http://www.clinicaltrials.gov/; reference number NCT00304980.
- Subjects :
- Adolescent
Adult
Animals
Artemether
Artemisinins therapeutic use
CD4 Lymphocyte Count
Drug Combinations
Ethanolamines therapeutic use
Female
Fluorenes therapeutic use
HIV Infections physiopathology
HIV Infections virology
Humans
Lumefantrine
Malaria, Falciparum parasitology
Male
Middle Aged
Pyrimethamine therapeutic use
Sulfadoxine therapeutic use
Treatment Failure
Treatment Outcome
Zambia
Antimalarials therapeutic use
HIV Infections immunology
HIV-1 pathogenicity
Immunosuppression Therapy
Malaria, Falciparum drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 194
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 16960779
- Full Text :
- https://doi.org/10.1086/507310