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The effect of topical doxycycline usage on gingival crevicular fluid MMP-8 levels of chronic and aggressive periodontitis patients: a pilot study.
- Source :
-
International journal of dental hygiene [Int J Dent Hyg] 2006 Aug; Vol. 4 (3), pp. 114-21. - Publication Year :
- 2006
-
Abstract
- The aim of this study was to evaluate the efficacy of topical subgingival application of doxycycline hyclate (DH) gel adjunctive to non-surgical periodontal therapy on gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)-8 levels in chronic and aggressive periodontitis patients. Forty teeth of 10 chronic periodontitis patients and 32 teeth of eight aggressive periodontitis patients were screened for 6 months. Scaling and root planing (SRP) was applied to the control sites and DH gel adjunctive to SRP was applied to the test sites of each patient simultaneously. GCF MMP-8 levels were analysed at baseline, 7 days; and at 1, 3 and 6 months by Sandwich Elisa Method. At 1, 3 and 6 months, probing depth (P < 0.0051) and plaque scores and bleeding on probing values (P = 0.000) significantly decreased in each group when compared with the baseline, but there was no statistically significant difference between the test and control sites. GCF MMP-8 levels reduced presenting statistically significant differences on 7 days, 1, 3 and 6 months in four of the groups (P < 0.05); however, intergroup differences were not statistically significant. Developing functional and immunological-based chair-side MMP tests might serve as useful adjunctive diagnostic tools when monitoring the effects of DH gel application.
- Subjects :
- Acute Disease
Adult
Aged
Analysis of Variance
Chronic Disease
Delayed-Action Preparations
Dental Scaling
Doxycycline administration & dosage
Female
Gels
Gingival Crevicular Fluid enzymology
Humans
Male
Matrix Metalloproteinase 8 analysis
Middle Aged
Periodontitis enzymology
Pilot Projects
Single-Blind Method
Statistics, Nonparametric
Anti-Infective Agents, Local administration & dosage
Doxycycline analogs & derivatives
Periodontitis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1601-5029
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of dental hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 16958738
- Full Text :
- https://doi.org/10.1111/j.1601-5037.2006.00174.x