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Remission of digestive insufficiency by islet transplantation to the pancreas.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 2006 Oct; Vol. 51 (10), pp. 1777-9. - Publication Year :
- 2006
-
Abstract
- Pancreatic digestive insufficiency is a common problem in both Type 1 and Type 2 diabetes and remains a serious consequence of diabetes in developing countries. The problem is not corrected by supportive therapies including exogenous insulin injections. It is our hypothesis that digestive insufficiency may be corrected or diminished by the transplantation of islets to the pancreas, thereby supplying islet hormones directly to acinar tissue analogous to the normal pancreas. Diabetic rats received 1000 syngeneic islets and dogs received 7600 autologous islets per kilogram as a transplant to the pancreas. Blood glucose and amylase concentrations were normalized in islet recipients in contrast with controls receiving no islets or islets transplanted to the renal capsule. These results suggest that diabetic digestive insufficiency may be corrected by intrapancreatic islet transplantation.
- Subjects :
- Amylases metabolism
Animals
Blood Glucose metabolism
Diabetes Complications blood
Diabetes Complications enzymology
Disease Models, Animal
Dogs
Exocrine Pancreatic Insufficiency metabolism
Female
Insulin blood
Male
Rats
Rats, Inbred Lew
Diabetes Complications complications
Exocrine Pancreatic Insufficiency etiology
Exocrine Pancreatic Insufficiency surgery
Islets of Langerhans Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 51
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16957994
- Full Text :
- https://doi.org/10.1007/s10620-006-9300-4