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Capsaicin and anaphylactic reactions in the guinea-pig airways.
- Source :
-
Agents and actions [Agents Actions] 1990 Apr; Vol. 30 (1-2), pp. 92-4. - Publication Year :
- 1990
-
Abstract
- Further evidence is reported on the influence exerted by capsaicin on the anaphylactic reaction evoked in actively sensitized guinea-pigs. In Herxheimer microshock induced by ovalbumin aerosol, pretreatment of animals with 100 micrograms/kg i.p. capsaicin prolonged the preconvulsion time when the drug was administered 3 h before antigen challenge. In contrast, the same dose of capsaicin injected 30 min before aerosol caused a shortening of latency of the respiratory symptomatology. The influence of the drug is no longer evident after 24 h. In "in vitro" experiments desensitization to capsaicin of tracheal preparations caused a reduction of histamine and SRS-A released during antigen challenge, in comparison to controls. Moreover, anaphylactic histamine release was increased in preparations perfused with 10(-8) M substance P. In conclusion, our findings confirm that neuropeptides may be involved in the pathogenesis of asthma by affecting release of mediators.
Details
- Language :
- English
- ISSN :
- 0065-4299
- Volume :
- 30
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Agents and actions
- Publication Type :
- Academic Journal
- Accession number :
- 1695470
- Full Text :
- https://doi.org/10.1007/BF01969007