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[A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient].
- Source :
-
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology [Nihon Shokakibyo Gakkai Zasshi] 2006 Sep; Vol. 103 (9), pp. 1044-9. - Publication Year :
- 2006
-
Abstract
- A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/microl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.
- Subjects :
- Abscess etiology
Adult
Anus Diseases etiology
Crohn Disease complications
Drug Therapy, Combination
Granulocyte Colony-Stimulating Factor therapeutic use
Humans
Ileitis etiology
Leukocyte Count
Male
Mesalamine administration & dosage
Bone Marrow drug effects
Crohn Disease drug therapy
Immunosuppressive Agents adverse effects
Mercaptopurine adverse effects
Neutropenia chemically induced
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0446-6586
- Volume :
- 103
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
- Publication Type :
- Academic Journal
- Accession number :
- 16953101