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17alpha-hydroxyprogesterone caproate for the prevention of preterm delivery: A cost-effectiveness analysis.
- Source :
-
Obstetrics and gynecology [Obstet Gynecol] 2006 Sep; Vol. 108 (3 Pt 1), pp. 492-9. - Publication Year :
- 2006
-
Abstract
- Objective: To evaluate whether the use of 17alpha-hydroxyprogesterone caproate for the prevention of recurrent preterm deliveries is cost-effective.<br />Methods: Using decision-analysis modeling, we compared the cost-effectiveness of using 17alpha-hydroxyprogesterone caproate in four subgroups: 1) Prior preterm deliveries less than 32 weeks; 2) prior preterm deliveries 32-37 weeks; 3) prior term delivery; and 4) no prior delivery. Each subgroup was compared with a "no treatment" group. Costs included those for 17alpha-hydroxyprogesterone caproate, hospital admissions, and complications from preterm deliveries. The main outcome measures include cost per quality-adjusted life-year gained and the number of preterm deliveries prevented. Secondary outcomes include neonatal complications prevented. One-way and multiway sensitivity analyses were performed.<br />Results: The use of 17alpha-hydroxyprogesterone caproate for the prevention of preterm deliveries result in cost-savings in women with prior preterm deliveries less than 32 weeks and 32-37 weeks. The sensitivity analyses revealed the model to be robust over a wide range of values for evaluated variables.<br />Conclusion: Within our baseline assumptions, 17alpha-hydroxyprogesterone caproate was associated with cost-savings when used for the prevention of preterm deliveries in women with prior preterm deliveries.
- Subjects :
- 17 alpha-Hydroxyprogesterone Caproate
Cost-Benefit Analysis
Decision Support Techniques
Female
Gestational Age
Health Care Costs
Hospitalization economics
Humans
Multivariate Analysis
Obstetric Labor Complications economics
Obstetric Labor Complications epidemiology
Obstetric Labor Complications prevention & control
Obstetric Labor, Premature economics
Obstetric Labor, Premature epidemiology
Obstetric Labor, Premature prevention & control
Parity
Pregnancy
Premature Birth economics
Premature Birth epidemiology
Risk Factors
Secondary Prevention
United States
Hydroxyprogesterones economics
Hydroxyprogesterones therapeutic use
Premature Birth prevention & control
Progestins economics
Progestins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0029-7844
- Volume :
- 108
- Issue :
- 3 Pt 1
- Database :
- MEDLINE
- Journal :
- Obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 16946206
- Full Text :
- https://doi.org/10.1097/01.AOG.0000232503.92206.d8