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Immunolocalization of basement membrane molecules in the stroma of salivary gland pleomorphic adenoma.
- Source :
-
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 1990 May; Vol. 19 (5), pp. 208-14. - Publication Year :
- 1990
-
Abstract
- In order to determine the participation of basement membrane molecules in formation of its characteristic stroma, 30 cases of salivary gland pleomorphic adenoma were examined by immunohistochemical staining for type IV collagen, laminin, heparan sulfate proteoglycan, and entactin. The stroma was histopathologically classified into four types: hyaline, fibrous, myxoid, and chondroid. Immunohistochemically, type IV collagen and laminin were more intensively localized in hyaline, fibrous and chondroid types of stroma, whereas heparan sulfate proteoglycan was more prominent in myxoid areas. The results suggest that the stroma contains these basement membrane components, which are possibly biosynthesized by epithelial tumor cells, and that histological variety of the stroma depends on proportion of local contents of each basement membrane molecule.
- Subjects :
- Adenoma, Pleomorphic classification
Adenoma, Pleomorphic ultrastructure
Antibodies
Chondroitin Sulfate Proteoglycans analysis
Collagen analysis
Epithelium analysis
Epithelium ultrastructure
Glycoproteins analysis
Heparan Sulfate Proteoglycans
Heparitin Sulfate analysis
Humans
Hyalin analysis
Immunoenzyme Techniques
Laminin analysis
Salivary Gland Neoplasms classification
Salivary Gland Neoplasms ultrastructure
Staining and Labeling
Adenoma, Pleomorphic analysis
Basement Membrane analysis
Membrane Glycoproteins
Salivary Gland Neoplasms analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0904-2512
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 1694244
- Full Text :
- https://doi.org/10.1111/j.1600-0714.1990.tb00827.x