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Spinocerebellar ataxia type 1, 2, and 3 and restless legs syndrome: striatal dopamine D2 receptor status investigated by [11C]raclopride positron emission tomography.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2006 Oct; Vol. 21 (10), pp. 1667-73. - Publication Year :
- 2006
-
Abstract
- In spinocerebellar ataxias (SCAs), up to 30% of patients complain of restless legs syndrome (RLS). In primary RLS, a putative role of the dopaminergic system has been postulated. To assess dopaminergic function in SCA1, 2, and 3, dopamine D(2) receptor binding potential (BP) was assessed by [(11)C]raclopride positron emission tomography in 10 SCA patients, 4 of whom suffered from RLS as demonstrated by polysomnography. BP was compared to 9 age-matched control subjects. In 2 SCA patients, striatal BP was clearly reduced (<2 SD below the mean of controls). However, there were no significant group differences between SCA and controls, largely owing to a significantly higher variance of striatal BP in SCA. BP was negatively correlated with disease duration. The fit suggests an increased BP in early stages, followed by a moderate decline in all quantified regions (caudate, dorsal putamen, ventral striatum) presumably reflecting a progressive loss of D(2) receptors. RLS in SCA was not accompanied by a significant reduction of D(2) receptor availability in the striatum. This missing correlation may point to an extrastriatal origin of RLS.
- Subjects :
- Adult
Ataxin-1
Ataxin-3
Ataxins
Corpus Striatum physiopathology
Female
Genotype
Humans
Machado-Joseph Disease genetics
Machado-Joseph Disease physiopathology
Male
Middle Aged
Nerve Tissue Proteins genetics
Neurologic Examination
Nuclear Proteins genetics
Occipital Lobe diagnostic imaging
Occipital Lobe physiopathology
Polysomnography
Repressor Proteins genetics
Restless Legs Syndrome physiopathology
Spinocerebellar Ataxias genetics
Spinocerebellar Ataxias physiopathology
Carbon Radioisotopes
Corpus Striatum diagnostic imaging
Machado-Joseph Disease diagnostic imaging
Positron-Emission Tomography
Raclopride
Receptors, Dopamine D2 physiology
Restless Legs Syndrome diagnostic imaging
Spinocerebellar Ataxias diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 0885-3185
- Volume :
- 21
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 16941469
- Full Text :
- https://doi.org/10.1002/mds.20978