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Human squamous cell carcinoma from skin: establishment and characterization of a new cell line (HSC-5).
- Source :
-
The Journal of dermatology [J Dermatol] 1990 Mar; Vol. 17 (3), pp. 143-8. - Publication Year :
- 1990
-
Abstract
- A new cell line, designated as HSC-5 and derived from human skin squamous cell carcinoma (SCC), has been established in vitro and maintained proliferative in continuous tissue culture for over two years. The cells grow in a monolayer in vitro and have anaplastic epithelioid features. The doubling time was about 35 hr at the 30th passage. Chromosome analysis showed hypotetraploidy with a modal number of 76. A trial of transplantation of the cultured cells into nude mice was not successful. Analysis of cytokeratins from HSC-5 by two-dimensional gel electrophoresis revealed polypeptides No. 5, 8, 13, 18 and 19. The cell line is available to other investigators.
Details
- Language :
- English
- ISSN :
- 0385-2407
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 1693926
- Full Text :
- https://doi.org/10.1111/j.1346-8138.1990.tb01615.x