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Monitoring cytochrome P-450 activity during rabeprazole treatment in patients with gastresophageal reflux disease.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 2006 Sep; Vol. 51 (9), pp. 1602-6. Date of Electronic Publication: 2006 Aug 22. - Publication Year :
- 2006
-
Abstract
- Proton pump inhibitors (PPIs) are the cornerstone in the treatment of gastresophageal reflux disease (GORD). PPIs are metabolized by the hepatic cytochrome P-450 enzymes (CYP-450). Rabeprazole is a PPI whose metabolism shows fewer interactions compared to other PPIs. In this study we evaluated the influence of rabeprazole administration on hepatic CYP-450 activity as measured by the (13)C-aminopyrine breath test ((13)C-ABT) in a group of patients with GORD. (13)C-ABT was performed on five GORD patients both before and after 1 week of rabeprazole administration (20 mg, b.i.d.). Pretreatment (13)C-ABT results were compared to posttreatment results. Pre- and posttreatment (13)C-ABT results for patients were compared to those obtained in five controls who did the test twice, with a 1-week interval in between. Before treatment, the (13)C-ABT results for the GORD patients did not significantly differ from those of healthy subjects. After treatment, we observed no significant modification of the (13)C-ABT in GORD patients compared to pretreatment values ((13)C-ABT %dose/hr, 10.56+/-1.31 versus 11.17+/-0.88; (13)C-ABT %cumulative dose, 8.08+/-1.11 versus 8.34+/-0.56). Posttreatment (13)C-ABT results were not significantly different from those obtained in controls at weekly repetition of the test. In patients with GORD, 1-week, full-dose rabeprazole does not display any significant interactions with CYP-450 activity.
- Subjects :
- 2-Pyridinylmethylsulfinylbenzimidazoles
Aminopyrine
Anti-Inflammatory Agents, Non-Steroidal
Breath Tests
Case-Control Studies
Female
Gastroesophageal Reflux enzymology
Humans
Male
Middle Aged
Monitoring, Physiologic
Omeprazole therapeutic use
Rabeprazole
Treatment Outcome
Anti-Ulcer Agents therapeutic use
Benzimidazoles therapeutic use
Cytochrome P-450 Enzyme System metabolism
Gastroesophageal Reflux drug therapy
Omeprazole analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 51
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16927149
- Full Text :
- https://doi.org/10.1007/s10620-005-9035-7