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Ultrastructural identification of neuropeptides in the central nervous system.
- Source :
-
Journal of electron microscopy technique [J Electron Microsc Tech] 1990 May; Vol. 15 (1), pp. 67-80. - Publication Year :
- 1990
-
Abstract
- A number of different neuropeptides have been described within presynaptic terminals at the ultrastructural level in the central nervous system. The majority of these neuropeptides share a common morphology with one another. Terminals containing neuropeptides have a population of small, clear vesicles associated with the active zone of the synapse and a lesser number of large, granular vesicles that are located at a distance from the active site of the synapse. It is believed that the large, granular vesicles act as a mechanism for the transport/storage of the neuropeptides, while the small, clear vesicles are thought to be acting as structures responsible for the release of the neurotransmitter/neuropeptide into the synaptic cleft. The neuropeptide containing terminals most often have asymmetrical junctions associated with their presynaptic membranes, although symmetrical junctions have been described with peptide containing terminals in a number of areas in the central nervous system. Neuropeptide containing terminals contact every part of the neuronal membrane; however, the majority of synaptic contacts involve portions of the dendritic shafts. Evidence is beginning to accumulate to indicate that for certain neuropeptides there is a specific spatial arrangement to their termination along the neuronal membrane.
Details
- Language :
- English
- ISSN :
- 0741-0581
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of electron microscopy technique
- Publication Type :
- Academic Journal
- Accession number :
- 1692587
- Full Text :
- https://doi.org/10.1002/jemt.1060150107