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CEACAM1 in cervical cancer and precursor lesions: association with human papillomavirus infection.
- Source :
-
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2006 Dec; Vol. 54 (12), pp. 1393-9. Date of Electronic Publication: 2006 Aug 21. - Publication Year :
- 2006
-
Abstract
- Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an adhesion molecule expressed in a wide variety of tissues including epithelial cells, leukocytes, and tumors that may establish both homotypic and heterotypic interactions. The aim of this work was to study the protein expression pattern of CEACAM1 in cervical cancer and precursor lesions in the context of human papillomavirus (HPV) infection. We used immunohistochemistry to analyze CEACAM1 expression in formalin-fixed, paraffin-embedded cervical tissues from 15 healthy women, 15 patients with low-grade squamous intraepithelial lesions (SIL), 15 patients with high-grade SIL, and 15 patients with squamous carcinomas. HPV types were identified by PCR. CEACAM1 was either undetectable (13/15) or low (2/15) in normal cervical tissues. By contrast, CEACAM1 expression was increased in high-grade SIL (10 samples staining intermediate/high and 4 samples staining low) as compared with low-grade SIL with undetectable (n=3) or low (n=12) expression. CEACAM1 expression was undetectable or low in cervical carcinoma. Our results suggest that CEACAM1 may be an interesting progression marker in SIL and cervical cancer, in particular due to reported immunoregulatory properties.
- Subjects :
- Adult
Antigens, CD analysis
Cell Adhesion Molecules analysis
Disease Progression
Female
Humans
Immunohistochemistry
Middle Aged
Papillomavirus Infections complications
Polymerase Chain Reaction
Precancerous Conditions chemistry
Precancerous Conditions virology
Sensitivity and Specificity
Uterine Cervical Neoplasms chemistry
Uterine Cervical Neoplasms virology
Uterine Cervical Dysplasia chemistry
Uterine Cervical Dysplasia virology
Antigens, CD biosynthesis
Cell Adhesion Molecules biosynthesis
Papillomavirus Infections pathology
Precancerous Conditions pathology
Uterine Cervical Neoplasms pathology
Uterine Cervical Dysplasia pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1554
- Volume :
- 54
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
- Publication Type :
- Academic Journal
- Accession number :
- 16924126
- Full Text :
- https://doi.org/10.1369/jhc.6A6921.2006