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Effects of colesevelam hydrochloride (WelChol) on biomarkers of inflammation in patients with mild hypercholesterolemia.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2006 Sep 01; Vol. 98 (5), pp. 641-3. Date of Electronic Publication: 2006 Jul 07. - Publication Year :
- 2006
-
Abstract
- Inflammation is pivotal in atherogenesis. High-sensitivity C-reactive protein (hs-CRP), the prototypic marker of inflammation, has been shown to predict cardiovascular events. Colesevelam hydrochloride (HCl) (WelChol, Sankyo Pharma Incorporated, Parsippany, New Jersey), a specifically engineered bile acid sequestrant, has been shown to be effective in lowering low-density lipoprotein (LDL) cholesterol levels in monotherapy and in combination with statins or fenofibrate. Previously, we have shown that statins lower hs-CRP levels; however, a paucity of data is available examining the effect of colesevelam HCl on hs-CRP levels. The aim of this study was to examine the effect of colesevelam HCl therapy (3.75 g/day for 6 weeks) on hs-CRP in patients with mild hypercholesterolemia in a randomized, double-blind, placebo-controlled study. Twenty-five subjects on colesevelam HCl and 23 subjects on placebo completed the study. The median baseline hs-CRP levels for the treatment and placebo groups are 3.4 and 3.1 mg/L, respectively. Colesevelam HCl therapy resulted in a significant reduction in LDL cholesterol levels (p < 0.001). No significant changes were found in total triglyceride or high-density lipoprotein cholesterol levels between the 2 groups. Furthermore, colesevelam HCl therapy resulted in a significant reduction in hs-CRP levels compared with baseline and placebo (15.9% and 18.7% median reduction, respectively, p < 0.025). No correlation was found between LDL cholesterol lowering and hs-CRP lowering (r = 0.3). In conclusion, our results show that colesevelam HCl monotherapy significantly lowered hs-CRP levels in a double-blind, placebo-controlled study.
- Subjects :
- Adult
Allylamine therapeutic use
Biomarkers blood
Cholesterol, LDL blood
Cholesterol, LDL drug effects
Colesevelam Hydrochloride
Double-Blind Method
Follow-Up Studies
Humans
Hypercholesterolemia blood
Treatment Outcome
Allylamine analogs & derivatives
C-Reactive Protein metabolism
Hypercholesterolemia drug therapy
Inflammation blood
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 98
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 16923452
- Full Text :
- https://doi.org/10.1016/j.amjcard.2006.03.043