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Regulation of B cell self-tolerance by BAFF.

Authors :
Brink R
Source :
Seminars in immunology [Semin Immunol] 2006 Oct; Vol. 18 (5), pp. 276-83. Date of Electronic Publication: 2006 Aug 17.
Publication Year :
2006

Abstract

To avoid the generation of pathogenic autoantibodies, self-reactive lymphocytes are deleted at several distinct checkpoints during B cell maturation. BAFF is required for mature B cell development and survival but causes B cell hyperplasia and autoimmunity when it is overexpressed. Self-reactive B cells have reduced responsiveness to BAFF and therefore die due to the limiting levels of BAFF available in vivo. Elevated BAFF expression subverts B cell self-tolerance by rescuing self-reactive B cells normally deleted relatively late during maturation. Strongly self-reactive B cells are deleted prior to expression of BAFF-R and are therefore resistant to rescue by BAFF.

Details

Language :
English
ISSN :
1044-5323
Volume :
18
Issue :
5
Database :
MEDLINE
Journal :
Seminars in immunology
Publication Type :
Academic Journal
Accession number :
16916609
Full Text :
https://doi.org/10.1016/j.smim.2006.04.003