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Regulation of B cell self-tolerance by BAFF.
- Source :
-
Seminars in immunology [Semin Immunol] 2006 Oct; Vol. 18 (5), pp. 276-83. Date of Electronic Publication: 2006 Aug 17. - Publication Year :
- 2006
-
Abstract
- To avoid the generation of pathogenic autoantibodies, self-reactive lymphocytes are deleted at several distinct checkpoints during B cell maturation. BAFF is required for mature B cell development and survival but causes B cell hyperplasia and autoimmunity when it is overexpressed. Self-reactive B cells have reduced responsiveness to BAFF and therefore die due to the limiting levels of BAFF available in vivo. Elevated BAFF expression subverts B cell self-tolerance by rescuing self-reactive B cells normally deleted relatively late during maturation. Strongly self-reactive B cells are deleted prior to expression of BAFF-R and are therefore resistant to rescue by BAFF.
- Subjects :
- Animals
Apoptosis physiology
Autoimmune Diseases etiology
Autoimmune Diseases immunology
Autoimmunity immunology
B-Cell Activating Factor genetics
B-Cell Activation Factor Receptor deficiency
B-Cell Activation Factor Receptor genetics
B-Cell Activation Factor Receptor immunology
Gene Rearrangement, B-Lymphocyte
Humans
Hyperplasia
Lymphocyte Activation
Lymphoid Tissue immunology
Mice
Mice, Transgenic
Models, Immunological
NF-kappa B metabolism
Organ Specificity
Recombinant Fusion Proteins immunology
Signal Transduction
B-Cell Activating Factor immunology
B-Lymphocyte Subsets immunology
Self Tolerance immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1044-5323
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Seminars in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16916609
- Full Text :
- https://doi.org/10.1016/j.smim.2006.04.003