Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP).

Authors :: Pignata S
Gallo C
Daniele B
Elba S
Giorgio A
Capuano G
Adinolfi LE
De Sio I
Izzo F
Farinati F
Del Naja C
Stanzione M
Castiglione F
Marone G
Cuomo O
Felder M
Gaeta GB
De Maio E
Di Maio M
Signoriello G
Perrone F
Source :: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2006 Sep; Vol. 59 (3), pp. 243-9. Date of Electronic Publication: 2006 Aug 17.
Publication Year :: 2006
Abstract: Purpose: To describe the characteristics at presentation and the outcome of elderly patients (> or =70 years old) with HCC, a retrospective analysis using a CLIP database was performed.<br />Patients and Methods: The database included 650 patients. Chi2-test, logistic and Cox model were applied.<br />Results: Baseline characteristics and stage were similarly among elderly (n=158) and non-elderly (n=492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p<0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival.<br />Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

Subjects :: Age Factors
Aged
Aged, 80 and over
Carcinoma, Hepatocellular mortality
Databases, Factual
Humans
Prognosis
Retrospective Studies
Survival Rate
Treatment Outcome
Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular therapy
Patient Care Planning statistics & numerical data
Practice Patterns, Physicians' statistics & numerical data

Full Text Access

Tools