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Description and management of cutaneous side effects during cetuximab or erlotinib treatments: a prospective study of 30 patients.
- Source :
-
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2006 Sep; Vol. 55 (3), pp. 429-37. Date of Electronic Publication: 2006 Jul 13. - Publication Year :
- 2006
-
Abstract
- Background: Drugs such as cetuximab or erlotinib, which inhibit the epidermal growth factor receptor, are increasingly being used in treatment of solid tumors. This has led to the appearance of new secondary effects.<br />Objective: We sought to describe the cutaneous side effects and their management in patients with cancer treated with cetuximab or erlotinib.<br />Methods: We clinically examined 30 patients determining type, frequency, treatment, and evolution of side effects.<br />Results: Most patients presented with a cutaneous reaction consisting of a follicular eruption, typically appearing in seborrheic areas within the first 15 days of treatment. Painful fissures in palms and soles and paronychia were the second most common cutaneous toxicities. We also noticed an alteration in hair growth at several months' follow-up. As these secondary effects responded well to treatment, few patients discontinued the antineoplastic therapy because of cutaneous toxicity.<br />Limitations: This was a prospective but uncontrolled study.<br />Conclusion: Although these new targeted therapies have low systemic toxicity because of their high specificity, cutaneous side effects are common and may be serious.
- Subjects :
- Aged
Antibodies, Monoclonal therapeutic use
Antibodies, Monoclonal, Humanized
Antineoplastic Agents therapeutic use
Cetuximab
Drug Eruptions pathology
ErbB Receptors antagonists & inhibitors
Erlotinib Hydrochloride
Female
Humans
Male
Middle Aged
Prospective Studies
Protein Kinase Inhibitors therapeutic use
Quinazolines therapeutic use
Antibodies, Monoclonal adverse effects
Antineoplastic Agents adverse effects
Drug Eruptions drug therapy
Neoplasms drug therapy
Protein Kinase Inhibitors adverse effects
Quinazolines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6787
- Volume :
- 55
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 16908348
- Full Text :
- https://doi.org/10.1016/j.jaad.2006.04.062