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HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial penicillin-binding proteins.
- Source :
-
Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 1990 Jan-Feb; Vol. 12 (1), pp. 43-6. - Publication Year :
- 1990
-
Abstract
- Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to five bacterial penicillin-binding proteins.
- Subjects :
- Amino Acid Sequence
Escherichia coli enzymology
Humans
Molecular Sequence Data
Penicillin-Binding Proteins
Sequence Homology, Nucleic Acid
Bacterial Proteins analysis
Carrier Proteins analysis
DNA Polymerase II analysis
HIV enzymology
Hexosyltransferases
Muramoylpentapeptide Carboxypeptidase analysis
Peptidyl Transferases
RNA-Directed DNA Polymerase analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0379-0355
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Methods and findings in experimental and clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1690323