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Boronated thymidine analogues for boron neutron capture therapy.

Authors :
Thirumamagal BT
Johnsamuel J
Cosquer GY
Byun Y
Yan J
Narayanasamy S
Tjarks W
Barth RF
Al-Madhoun AS
Eriksson S
Source :
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2006; Vol. 25 (8), pp. 861-6.
Publication Year :
2006

Abstract

Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.

Details

Language :
English
ISSN :
1525-7770
Volume :
25
Issue :
8
Database :
MEDLINE
Journal :
Nucleosides, nucleotides & nucleic acids
Publication Type :
Academic Journal
Accession number :
16901817
Full Text :
https://doi.org/10.1080/15257770600793844