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Variations in chemokine receptor and cytokine expression during pregnancy in multiple sclerosis patients.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2006 Aug; Vol. 12 (4), pp. 421-7. - Publication Year :
- 2006
-
Abstract
- Although several T cell-mediated autoimmune diseases have shown a reduction in their clinical disease activity during pregnancy, the underlying mechanisms by which pregnancy causes such a beneficial effect on the disease activity are not fully understood. We performed a longitudinal study of chemokine receptors (CCR3, CCR4, CCRS, CXCR3, CXCR4) by flow cytometry in different subsets of peripheral blood mononuclear cells (PBMC) during pregnancy in multiple sclerosis (MS) patients. The levels of cytokine mRNA expression (IL-10, IFN-gamma) were also investigated by real-time quantitative reverse transcription polymerase chain reaction. The expression of CXCR3 by CD4 and CD8 positive T cells was decreased to a statistically significant extent during the second trimester of pregnancy. CD4 and CD8 T cells showed a statistically significant increase in the expression of CXCR4 during the third trimester of pregnancy. At the mRNA expression level, an increase in the IL-10/IFN-gamma ratio was observed during pregnancy, especially during the third trimester. These findings indicate immunomodulatory effects of pregnancy on the expression of chemokine receptors and cytokines, which may be related to changes in the clinical disease activity of T cell-mediated autoimmune diseases, such as MS.
- Subjects :
- Adult
B-Lymphocytes metabolism
B-Lymphocytes physiology
CD4-Positive T-Lymphocytes metabolism
CD4-Positive T-Lymphocytes physiology
CD8-Positive T-Lymphocytes metabolism
CD8-Positive T-Lymphocytes physiology
Female
Gene Expression immunology
Humans
Killer Cells, Natural metabolism
Killer Cells, Natural physiology
Monocytes metabolism
Monocytes physiology
Pregnancy
RNA, Messenger metabolism
Receptors, CCR3
Receptors, CCR4
Receptors, CCR5 genetics
Receptors, CCR5 metabolism
Receptors, CXCR3
Receptors, CXCR4 genetics
Receptors, CXCR4 metabolism
Receptors, Chemokine metabolism
Interferon-gamma genetics
Interleukin-10 genetics
Multiple Sclerosis immunology
Pregnancy Complications immunology
Receptors, Chemokine genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1352-4585
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 16900755
- Full Text :
- https://doi.org/10.1191/1352458506ms1287oa