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Disturbance of response to acute thermal pain in naturally occurring cholecystokinin-a receptor gene knockout Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
- Source :
-
Journal of pharmacological sciences [J Pharmacol Sci] 2006 Aug; Vol. 101 (4), pp. 280-5. Date of Electronic Publication: 2006 Aug 05. - Publication Year :
- 2006
-
Abstract
- Otsuka Long-Evans Tokushima Fatty (OLETF) rats lack cholecystokinin-A receptor (CCK-AR) because of a genetic abnormality. We observed that body temperature homeostasis in response to changes in ambient temperature was deteriorated in OLETF rats, while the functions of the signal outputs from the hypothalamus to effectors were not impaired. Deteriorated homeostasis was also seen in CCK-AR deficient (-/-) mice. In the present study, we examined whether the sensory pathway involved in transmitting signals about temperature from the skin to the brain was impaired in OLETF rats. To elucidate the involvement of CCK-AR function, we conducted the same experiment in CCK-AR(-/-) mice. Responses to thermal pain were assessed using the Hargreaves' plantar test apparatus. Shortening of withdrawal latency was observed in OLETF rats compared to control rats, indicating thermal hyperalgesia. Behavioral responses following paw withdrawal were disturbed in OLETF rats. The 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid contents in the hippocampus and frontal cortex of OLETF rats were significantly higher than in those of the controls. CCK-AR(-/-) mice did not show any differences from wild-type mice. In conclusion, OLETF rats showed thermal hyperalgesia and disturbed responses to thermal pain, and an alteration of 5-HT function might have a role in this disturbance.
- Subjects :
- Acute Disease
Animals
Cerebral Cortex metabolism
Corpus Striatum metabolism
Dopamine metabolism
Hippocampus metabolism
Hydroxyindoleacetic Acid metabolism
Hyperalgesia etiology
Infrared Rays adverse effects
Male
Mice
Mice, Knockout
Norepinephrine metabolism
Pain Measurement instrumentation
Pain Measurement methods
Pain Threshold
Rats
Rats, Inbred OLETF
Reaction Time
Receptor, Cholecystokinin A deficiency
Receptor, Cholecystokinin A genetics
Serotonin metabolism
Hyperalgesia physiopathology
Receptor, Cholecystokinin A physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-8613
- Volume :
- 101
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16891771
- Full Text :
- https://doi.org/10.1254/jphs.fp0060300