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Angiographic coronary artery disease is associated with progressively higher levels of fasting plasma glucose.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2007 Feb; Vol. 75 (2), pp. 207-13. Date of Electronic Publication: 2006 Aug 02. - Publication Year :
- 2007
-
Abstract
- This study evaluated the association between progressively higher levels of fasting glycemia (G) and insulin resistance parameters with coronary artery disease (CAD) in patients referred for coronary angiography. All 145 patients (age 58.4+/-0.9 years, 51.7% men) underwent clinical and laboratory evaluation before coronary angiography and subjects were divided into four groups: normal (N, <88 mg/dl), high-normal (H-N, 89-99 mg/dl), impaired fasting glucose (IFG, 100-125 mg/dl) and diabetes (DM, >126 mg/dl or known diabetics). Arteriographic evidence of CAD was determined by two criteria: (1) a 30% or greater diameter stenosis in at least one major coronary artery; (2) a 70% or greater diameter stenosis in at least one major coronary artery. HOMA-IR increased progressively according to each group: N=1.74+/-0.2, H-N=3.14+/-0.3, IFG=4.67+/-0.6 and DM=8.00+/-2.9; p=0.001. The proportion of patients with CAD according to both criteria increased with each G level: CAD criteria 1: N=39.4%, H-N=50%, IFG=60% and DM=69.6%, p=0.006; CAD criteria 2: N=27.3%, H-N=30%, IFG=36% and DM=50%, p=0.03. We demonstrated a significant association between subtle disturbances of the glucose metabolism, assessed by subnormal levels of fasting glucose and insulin resistance parameters, and angiographically documented coronary artery disease.
- Subjects :
- Body Mass Index
Cholesterol blood
Cholesterol, HDL blood
Fasting
Female
Humans
Hypertension epidemiology
Male
Middle Aged
Blood Glucose metabolism
Coronary Angiography adverse effects
Coronary Disease blood
Coronary Disease diagnostic imaging
Diabetic Angiopathies blood
Diabetic Angiopathies diagnostic imaging
Hyperglycemia etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8227
- Volume :
- 75
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 16887232
- Full Text :
- https://doi.org/10.1016/j.diabres.2006.06.003