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[Pharmacogenetics of indirect anticoagulants: value of genotype for improvement of efficacy and safety of therapy].
- Source :
-
Kardiologiia [Kardiologiia] 2006; Vol. 46 (7), pp. 72-7. - Publication Year :
- 2006
-
Abstract
- The review is devoted to the contemporary state of the problem of pharmacogenetics of indirect anticoagulants. At present there are data about effects of allele variants of CYP2C9, VKORC1, APOE genes on efficacy and safety of therapy with indirect anticoagulants. Detection of these variants is a perspective way to individualization of therapy with indirect anticoagulants.
- Subjects :
- Anticoagulants adverse effects
Biotransformation
Cytochrome P-450 CYP2C9
Genotype
Humans
Pharmacogenetics
Polymorphism, Genetic
Vitamin K Epoxide Reductases
Anticoagulants pharmacokinetics
Anticoagulants therapeutic use
Apolipoproteins E genetics
Aryl Hydrocarbon Hydroxylases genetics
Mixed Function Oxygenases genetics
Subjects
Details
- Language :
- Russian
- ISSN :
- 0022-9040
- Volume :
- 46
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Kardiologiia
- Publication Type :
- Academic Journal
- Accession number :
- 16883270