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[Biological action and clinical application of shark liver oil].
- Source :
-
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego [Pol Merkur Lekarski] 2006 May; Vol. 20 (119), pp. 598-601. - Publication Year :
- 2006
-
Abstract
- Fish oils contain several active compounds that modify cell activity and influence various functions of the body. Shark liver oils are rich in alkylglycerols and squalene, but contain relatively low amounts of n-3 polyunsaturated fatty acids. Alkylglycerols may control immune response possibly throw modification of platelet activating factor (PAF) and diacylglycerol (DAG) production. Squalene enhances antigen presentation and induction of inflammatory response. Moreover, alkylglycerols and squalene have antitumour activity, that is possibly based on different mechanisms, ie., induction of apoptosis of neoplastic cells, suppression of signal transduction, inhibition of angiogenesis and promoting of transmembrane transport of cytotoxic agents. Shark liver oil has been found to be useful in treatment of conditions resulted from inadequate immune response, and in adjunctive treatment of several types of cancer.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Apoptosis drug effects
Diglycerides biosynthesis
Humans
Inflammation immunology
Neoplasms drug therapy
Neovascularization, Pathologic prevention & control
Platelet Activating Factor drug effects
Sharks
Signal Transduction drug effects
Fish Oils pharmacology
Fish Oils therapeutic use
Squalene pharmacology
Squalene therapeutic use
Subjects
Details
- Language :
- Polish
- ISSN :
- 1426-9686
- Volume :
- 20
- Issue :
- 119
- Database :
- MEDLINE
- Journal :
- Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
- Publication Type :
- Academic Journal
- Accession number :
- 16875171