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Induction of salivary antibodies to inhibit Candida albicans adherence to human epithelial cells by tonsillar immunization in rabbits.
- Source :
-
FEMS immunology and medical microbiology [FEMS Immunol Med Microbiol] 2006 Aug; Vol. 47 (3), pp. 398-404. - Publication Year :
- 2006
-
Abstract
- To examine the possibility of a vaccine for Candida albicans infection in the oral cavity, we induced salivary antibodies by immunization of killed-C. albicans ATCC 18804 on the palatine tonsils of rabbits. The enzyme-linked immunosorbent assay reaction of salivary antibodies was high against C. albicans serotype A. The saliva antibodies greatly inhibited C. albicans adherence to cloned epithelial cells from human gingiva. Tonsillar immunizations of C. albicans ATCC 18804 induce salivary antibodies that prevent C. albicans adherence to epithelial cells, and thus should prove useful in the prevention of oral candidiasis caused by C. albicans serotype A.
- Subjects :
- Animals
Antibodies, Fungal biosynthesis
Antibody Specificity
Antigens immunology
Candida albicans physiology
Cell Adhesion
Cell Line, Tumor
Enzyme-Linked Immunosorbent Assay
Gingiva cytology
Humans
Rabbits
Antibodies, Fungal immunology
Candida albicans immunology
Immunization methods
Palatine Tonsil immunology
Saliva immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0928-8244
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- FEMS immunology and medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 16872376
- Full Text :
- https://doi.org/10.1111/j.1574-695X.2006.00102.x