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Gene expression profiling of gut mucosa and mesenteric lymph nodes in simian immunodeficiency virus-infected macaques with divergent disease course.
- Source :
-
Journal of medical primatology [J Med Primatol] 2006 Aug; Vol. 35 (4-5), pp. 261-9. - Publication Year :
- 2006
-
Abstract
- Background: Although the majority of drug-naïve HIV-infected patients develop acquired immunodeficiency syndrome (AIDS), a small percentage remains asymptomatic without therapeutic intervention.<br />Methods: We have utilized the simian immunodeficiency virus (SIV)-infected rhesus macaque model to gain insights into the molecular mechanisms of long-term protection against simian AIDS.<br />Results: Chronically SIV-infected macaques with disease progression had high viral loads and CD4(+) T-cell depletion in mucosal tissue and peripheral blood. These animals displayed pathologic changes in gut-associated lymphoid tissue (GALT) and mesenteric lymph node that coincided with increased expression of genes associated with interferon induction, inflammation and immune activation. In contrast, the animal with long-term asymptomatic infection suppressed viral replication and maintained CD4(+) T cells in both GALT and peripheral blood while decreasing expression of genes involved in inflammation and immune activation.<br />Conclusions: Our findings suggest that reduced immune activation and effective repair and regeneration of mucosal tissues correlate with long-term survival in SIV-infected macaques.
- Subjects :
- Animals
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Disease Models, Animal
Female
Flow Cytometry
Gene Expression Profiling
Immunity, Mucosal immunology
Immunohistochemistry
Intestinal Mucosa immunology
Intestinal Mucosa pathology
Intestinal Mucosa virology
Jejunum immunology
Jejunum pathology
Jejunum physiology
Jejunum virology
Lymphoid Tissue immunology
Lymphoid Tissue pathology
Lymphoid Tissue virology
Macaca mulatta
Oligonucleotide Array Sequence Analysis
Simian Acquired Immunodeficiency Syndrome immunology
Simian Acquired Immunodeficiency Syndrome virology
Simian Immunodeficiency Virus immunology
Virus Replication physiology
Immunity, Mucosal genetics
Intestinal Mucosa physiology
Lymphoid Tissue physiology
Simian Acquired Immunodeficiency Syndrome genetics
Simian Immunodeficiency Virus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0047-2565
- Volume :
- 35
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Journal of medical primatology
- Publication Type :
- Academic Journal
- Accession number :
- 16872289
- Full Text :
- https://doi.org/10.1111/j.1600-0684.2006.00180.x