Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides.

Authors :: Adams Y
Freeman C
Schwartz-Albiez R
Ferro V
Parish CR
Andrews KT
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2006 Aug; Vol. 50 (8), pp. 2850-2.
Publication Year :: 2006
Abstract: A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 microM) and demonstrated modest adhesion inhibition to cell surface CSA.

Subjects :: Animals
Cell Adhesion drug effects
Chondroitin Sulfates pharmacology
Dose-Response Relationship, Drug
In Vitro Techniques
Inhibitory Concentration 50
Oligosaccharides metabolism
Plasmodium falciparum cytology
Sulfates chemistry
Antimalarials pharmacology
Chondroitin Sulfates physiology
Heparitin Sulfate pharmacology
Oligosaccharides pharmacology
Plasmodium falciparum drug effects

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