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The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Sep 15; Vol. 16 (18), pp. 4723-7. Date of Electronic Publication: 2006 Jul 25. - Publication Year :
- 2006
-
Abstract
- Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in an animal model of diet-induced obesity is presented.
- Subjects :
- Animals
Body Weight drug effects
Mice
Mice, Inbred AKR
Models, Molecular
Molecular Structure
Pyrimidinones chemical synthesis
Receptors, Pituitary Hormone metabolism
Structure-Activity Relationship
Sulfhydryl Compounds chemistry
Pyrimidinones chemistry
Pyrimidinones pharmacology
Receptors, Pituitary Hormone antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16870432
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.07.008