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Causes of pure aortic regurgitation in patients having isolated aortic valve replacement at a single US tertiary hospital (1993 to 2005).
- Source :
-
Circulation [Circulation] 2006 Aug 01; Vol. 114 (5), pp. 422-9. Date of Electronic Publication: 2006 Jul 24. - Publication Year :
- 2006
-
Abstract
- Background: The causes of aortic regurgitation (AR) severe enough to warrant aortic valve replacement (AVR) have received little attention in the last 20 years.<br />Methods and Results: We analyzed the causes of pure AR in 268 patients > 20 years of age having isolated AVR at Baylor University Medical Center from 1993 to 2005 that was unassociated with mitral stenosis, mitral valve replacement, or a previous operation involving a cardiac valve or ascending aorta. In 122 patients (46%), the AR resulted from a problem with the aortic valve: congenital malformation unassociated with infective endocarditis, 66 patients (54%); infective endocarditis, 46 patients (38%; 15 with bicuspid valves); probable rheumatic heart disease, 8 patients (6%); and miscellaneous, 2 patients (2%). In the other 146 patients (54%), the AR was the consequence of a condition affecting the ascending aorta: dissection, 28 patients (19%); the Marfan syndrome or its forme fruste variety, 15 patients (10%); aortitis, 12 patients (8%), and in the remaining 91 patients (62%), the cause of the AR was not determined. This latter group was the oldest (mean age 66 years), 83 (91%) had hypertension, 26 (29%) had small calcific deposits in the valve cusps, and 46 (51%) had simultaneous coronary artery bypass grafting.<br />Conclusions: The causes of pure AR severe enough to warrant isolated AVR are diverse. The most common category in this study was "cause unclear."
- Subjects :
- Adult
Aged
Aged, 80 and over
Aortic Dissection complications
Aortic Dissection pathology
Aortic Dissection physiopathology
Aortic Valve pathology
Aortic Valve physiopathology
Aortic Valve Insufficiency physiopathology
Aortitis complications
Aortitis pathology
Aortitis physiopathology
Coronary Artery Bypass adverse effects
Endocarditis, Bacterial complications
Endocarditis, Bacterial pathology
Endocarditis, Bacterial physiopathology
Female
Heart Defects, Congenital complications
Heart Defects, Congenital pathology
Heart Defects, Congenital physiopathology
Humans
Hypertension pathology
Hypertension physiopathology
Male
Marfan Syndrome complications
Marfan Syndrome pathology
Marfan Syndrome physiopathology
Middle Aged
Mitral Valve Stenosis complications
Mitral Valve Stenosis pathology
Mitral Valve Stenosis physiopathology
Retrospective Studies
Rheumatic Heart Disease complications
Rheumatic Heart Disease pathology
Rheumatic Heart Disease physiopathology
Aortic Valve surgery
Aortic Valve Insufficiency etiology
Aortic Valve Insufficiency surgery
Heart Valve Prosthesis statistics & numerical data
Hospitals, University statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4539
- Volume :
- 114
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 16864725
- Full Text :
- https://doi.org/10.1161/CIRCULATIONAHA.106.622761