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Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice.
- Source :
-
Infection and immunity [Infect Immun] 2006 Aug; Vol. 74 (8), pp. 4939-44. - Publication Year :
- 2006
-
Abstract
- One of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especially in the case of PsaA, which was shown to have homologs with elevated sequence identity in other viridans group streptococci. In this work, we demonstrate that intranasal immunization with a cholera toxin B subunit-PsaA fusion protein is able to protect mice against colonization with S. pneumoniae but does not significantly alter the natural oral or nasopharyngeal microbiota of mice.
- Subjects :
- Administration, Intranasal
Animals
Bacterial Proteins genetics
Bacterial Proteins immunology
Bacterial Proteins metabolism
Cholera Toxin genetics
Cholera Toxin immunology
Cholera Toxin metabolism
Female
Gram-Positive Bacteria growth & development
Gram-Positive Bacteria isolation & purification
Immunization
Immunoglobulin A blood
Immunoglobulin G blood
Mice
Mice, Inbred C57BL
Mouth microbiology
Nasopharynx microbiology
Pneumococcal Infections immunology
Pneumococcal Infections microbiology
Pneumococcal Infections prevention & control
Pneumococcal Vaccines immunology
Recombinant Fusion Proteins immunology
Streptococcus pneumoniae growth & development
Antibodies, Bacterial blood
Bacterial Proteins administration & dosage
Cholera Toxin administration & dosage
Pneumococcal Vaccines administration & dosage
Recombinant Fusion Proteins administration & dosage
Streptococcus pneumoniae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 74
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 16861686
- Full Text :
- https://doi.org/10.1128/IAI.00134-06