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The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.
- Source :
-
Molecular cell [Mol Cell] 2006 Jul 21; Vol. 23 (2), pp. 241-50. - Publication Year :
- 2006
-
Abstract
- Regulation of gene expression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to high osmolarity results in activation of the SAPK Hog1, which associates with transcription factors bound at target promoters and stimulates transcriptional initiation. Unexpectedly, activated Hog1 also associates with elongating Pol II and components of the elongation complex. Hog1 is selectively recruited to the entire coding region of osmotic stress genes, but not to constitutively expressed genes. Selective association of Hog1 with the transcribed region of osmoresponsive genes is determined by the 3' untranslated region (3' UTR). Lastly, Hog1 is important for the amount of the RNA polymerase II (Pol II) elongation complex and of mRNA produced from genes containing osmoresponsive coding regions. Thus, in addition to its various functions during transcriptional initiation, Hog1 behaves as a transcriptional elongation factor that is selective for genes induced upon osmotic stress.
- Subjects :
- 3' Untranslated Regions metabolism
Fungal Proteins genetics
Fungal Proteins metabolism
Mitogen-Activated Protein Kinases metabolism
Models, Biological
Osmotic Pressure
RNA Polymerase II metabolism
RNA, Messenger biosynthesis
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae Proteins metabolism
Transcriptional Elongation Factors metabolism
Gene Expression Regulation, Fungal
Mitogen-Activated Protein Kinases genetics
Saccharomyces cerevisiae physiology
Saccharomyces cerevisiae Proteins genetics
Transcriptional Elongation Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-2765
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecular cell
- Publication Type :
- Academic Journal
- Accession number :
- 16857590
- Full Text :
- https://doi.org/10.1016/j.molcel.2006.05.031